Human KF1 (RNF103) activation kit by CRISPRa

CAT#: GA105332

RNF103 CRISPRa kit - CRISPR gene activation of human ring finger protein 103

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNF103
• Locus ID: 7844
• Kit Components:

  GA105332G1, RNF103 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105332G2, RNF103 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105332G3, RNF103 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001198951, NM_001198952, NM_005667
• Synonyms: HKF-1; KF-1; KF1; ZFP-103; ZFP103
• Summary: The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]