Human MAPKAP Kinase 3 (MAPKAPK3) activation kit by CRISPRa

CAT#: GA105342

MAPKAPK3 CRISPRa kit - CRISPR gene activation of human MAPK activated protein kinase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAPKAPK3
• Locus ID: 7867
• Kit Components:

  GA105342G1, MAPKAPK3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105342G2, MAPKAPK3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105342G3, MAPKAPK3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243925, NM_001243926, NM_004635
• Synonyms: 3PK; MAPKAP-K3; MAPKAP3; MAPKAPK-3; MK-3
• Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]