Human USP7 activation kit by CRISPRa

CAT#: GA105346

USP7 CRISPRa kit - CRISPR gene activation of human ubiquitin specific peptidase 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: USP7
• Locus ID: 7874
• Kit Components:

  GA105346G1, USP7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105346G2, USP7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105346G3, USP7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286457, NM_001286458, NM_003470, NM_001321858, NR_135826
• Synonyms: HAUSP; TEF1
• Summary: The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016]