Human EPM2A activation kit by CRISPRa

CAT#: GA105367

EPM2A CRISPRa kit - CRISPR gene activation of human EPM2A glucan phosphatase, laforin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EPM2A
• Locus ID: 7957
• Kit Components:

  GA105367G1, EPM2A gRNA vector 1 in pCas-Guide-CRISPRa

  GA105367G2, EPM2A gRNA vector 2 in pCas-Guide-CRISPRa

  GA105367G3, EPM2A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001018041, NM_005670, NM_001360057, NM_001360064, NM_001360071, NR_153397, NR_153398, NM_001368132, NM_001368129, NM_001368130, NM_001368131
• Synonyms: EPM2; MELF
• Summary: This gene encodes a dual-specificity phosphatase and may be involved in the regulation of glycogen metabolism. The protein acts on complex carbohydrates to prevent glycogen hyperphosphorylation, thus avoiding the formation of insoluble aggregates. Loss-of-function mutations in this gene have been associated with Lafora disease, a rare, adult-onset recessive neurodegenerative disease, which results in myoclonus epilepsy and usually results in death several years after the onset of symptoms. The disease is characterized by the accumulation of insoluble particles called Lafora bodies, which are derived from glycogen. [provided by RefSeq, Jan 2018]