Human FGF 23 (FGF23) activation kit by CRISPRa

CAT#: GA105400

FGF23 CRISPRa kit - CRISPR gene activation of human fibroblast growth factor 23

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FGF23
• Locus ID: 8074
• Kit Components:

  GA105400G1, FGF23 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105400G2, FGF23 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105400G3, FGF23 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020638
• Synonyms: ADHR; FGFN; HPDR2; HYPF; PHPTC
• Summary: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]