Human USP5 activation kit by CRISPRa

CAT#: GA105402

USP5 CRISPRa kit - CRISPR gene activation of human ubiquitin specific peptidase 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: USP5
• Locus ID: 8078
• Kit Components:

  GA105402G1, USP5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105402G2, USP5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105402G3, USP5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001098536, NM_003481
• Synonyms: ISOT
• Summary: Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]). [supplied by OMIM, Mar 2010]