Human CDK2AP1 activation kit by CRISPRa

CAT#: GA105411

CDK2AP1 CRISPRa kit - CRISPR gene activation of human cyclin dependent kinase 2 associated protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDK2AP1
• Locus ID: 8099
• Kit Components:

  GA105411G1, CDK2AP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105411G2, CDK2AP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105411G3, CDK2AP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001270433, NM_001270434, NM_004642, NR_073007, NR_073008, N41298
• Synonyms: doc-1; DOC1; DORC1; p12DOC-1; ST19
• Summary: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]