Human Frizzled 6 (FZD6) activation kit by CRISPRa

CAT#: GA105488

FZD6 CRISPRa kit - CRISPR gene activation of human frizzled class receptor 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FZD6
• Locus ID: 8323
• Kit Components:

  GA105488G1, FZD6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105488G2, FZD6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105488G3, FZD6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164615, NM_001164616, NM_001317796, NM_003506, NR_133921
• Synonyms: FZ-6; FZ6; HFZ6; NDNC10
• Summary: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. [provided by RefSeq, Aug 2011]