Human Frizzled 7 (FZD7) activation kit by CRISPRa

CAT#: GA105489

FZD7 CRISPRa kit - CRISPR gene activation of human frizzled class receptor 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FZD7
• Locus ID: 8324
• Kit Components:

  GA105489G1, FZD7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105489G2, FZD7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105489G3, FZD7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003507
• Synonyms: FzE3
• Summary: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]