Human Frizzled 8 (FZD8) activation kit by CRISPRa

CAT#: GA105490

FZD8 CRISPRa kit - CRISPR gene activation of human frizzled class receptor 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FZD8
• Locus ID: 8325
• Kit Components:

  GA105490G1, FZD8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105490G2, FZD8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105490G3, FZD8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_031866
• Synonyms: FZ-8; hFZ8
• Summary: This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]