Human MAD1 (MAD1L1) activation kit by CRISPRa

CAT#: GA105535

MAD1L1 CRISPRa kit - CRISPR gene activation of human mitotic arrest deficient 1 like 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAD1L1
• Locus ID: 8379
• Kit Components:

  GA105535G1, MAD1L1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105535G2, MAD1L1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105535G3, MAD1L1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001013836, NM_001013837, NM_001304523, NM_001304524, NM_001304525, NM_003550
• Synonyms: MAD1; PIG9; TP53I9; TXBP181
• Summary: MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]