Human Calcium independent Phospholipase A2 (PLA2G6) activation kit by CRISPRa

CAT#: GA105547

PLA2G6 CRISPRa kit - CRISPR gene activation of human phospholipase A2 group VI

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PLA2G6
• Locus ID: 8398
• Kit Components:

  GA105547G1, PLA2G6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105547G2, PLA2G6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105547G3, PLA2G6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001004426, NM_001199562, NM_003560, NM_001349864, NM_001349865, NM_001349866, NM_001349867, NM_001349868, NM_001349869
• Synonyms: CaI-PLA2; GVI; INAD1; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PNPLA9
• Summary: The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]