Human SPOP activation kit by CRISPRa

CAT#: GA105552

SPOP CRISPRa kit - CRISPR gene activation of human speckle type BTB/POZ protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPOP
• Locus ID: 8405
• Kit Components:

  GA105552G1, SPOP gRNA vector 1 in pCas-Guide-CRISPRa

  GA105552G2, SPOP gRNA vector 2 in pCas-Guide-CRISPRa

  GA105552G3, SPOP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001007226, NM_001007227, NM_001007228, NM_001007229, NM_001007230, NM_003563, NM_001370730, NM_001370731, NM_001370732
• Synonyms: BTBD32; TEF2
• Summary: This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]