Human Nck beta (NCK2) activation kit by CRISPRa

CAT#: GA105574

NCK2 CRISPRa kit - CRISPR gene activation of human NCK adaptor protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NCK2
• Locus ID: 8440
• Kit Components:

  GA105574G1, NCK2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105574G2, NCK2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105574G3, NCK2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001004720, NM_001004722, NM_003581
• Synonyms: GRB4; NCKbeta
• Summary: This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]