Human CDC42 binding protein kinase alpha (CDC42BPA) activation kit by CRISPRa

CAT#: GA105600

CDC42BPA CRISPRa kit - CRISPR gene activation of human CDC42 binding protein kinase alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDC42BPA
• Locus ID: 8476
• Kit Components:

  GA105600G1, CDC42BPA gRNA vector 1 in pCas-Guide-CRISPRa

  GA105600G2, CDC42BPA gRNA vector 2 in pCas-Guide-CRISPRa

  GA105600G3, CDC42BPA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003607, NM_014826, NM_001366010, NM_001366011, NM_001366019
• Synonyms: MRCK; MRCKA; PK428
• Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]