Human Gemin 2 (GEMIN2) activation kit by CRISPRa

CAT#: GA105608

GEMIN2 CRISPRa kit - CRISPR gene activation of human gem nuclear organelle associated protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GEMIN2
• Locus ID: 8487
• Kit Components:

  GA105608G1, GEMIN2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105608G2, GEMIN2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105608G3, GEMIN2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001009182, NM_001009183, NM_003616
• Synonyms: SIP1; SIP1-delta
• Summary: This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]