Human Neurotrypsin (PRSS12) activation kit by CRISPRa

CAT#: GA105611

PRSS12 CRISPRa kit - CRISPR gene activation of human serine protease 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PRSS12
• Locus ID: 8492
• Kit Components:

  GA105611G1, PRSS12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105611G2, PRSS12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105611G3, PRSS12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003619
• Synonyms: BSSP-3; BSSP3; MRT1
• Summary: This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017]