Human Liprin alpha 1 (PPFIA1) activation kit by CRISPRa

CAT#: GA105618

PPFIA1 CRISPRa kit - CRISPR gene activation of human PTPRF interacting protein alpha 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PPFIA1
• Locus ID: 8500
• Kit Components:

  GA105618G1, PPFIA1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105618G2, PPFIA1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105618G3, PPFIA1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003626, NM_177423, NR_045286
• Synonyms: LIP.1; LIP1; LIPRIN
• Summary: The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]