Human IKAP (IKBKAP) activation kit by CRISPRa

CAT#: GA105634

ELP1 CRISPRa kit - CRISPR gene activation of human elongator complex protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IKBKAP
• Locus ID: 8518
• Kit Components:

  GA105634G1, IKBKAP gRNA vector 1 in pCas-Guide-CRISPRa

  GA105634G2, IKBKAP gRNA vector 2 in pCas-Guide-CRISPRa

  GA105634G3, IKBKAP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318360, NM_003640, NM_001330749
• Synonyms: DYS; ELP1; FD; IKAP; IKI3; TOT1
• Summary: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]