Human Apolipoprotein L 1 (APOL1) activation kit by CRISPRa

CAT#: GA105656

APOL1 CRISPRa kit - CRISPR gene activation of human apolipoprotein L1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: APOL1
• Locus ID: 8542
• Kit Components:

  GA105656G1, APOL1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105656G2, APOL1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105656G3, APOL1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136540, NM_001136541, NM_003661, NM_145343, NM_145344, NM_001362927
• Synonyms: APO-L; APOL; APOL-I; FSGS4
• Summary: This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]