Human HPS2 (AP3B1) activation kit by CRISPRa

CAT#: GA105660

AP3B1 CRISPRa kit - CRISPR gene activation of human adaptor related protein complex 3 subunit beta 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AP3B1
• Locus ID: 8546
• Kit Components:

  GA105660G1, AP3B1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105660G2, AP3B1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105660G3, AP3B1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001271769, NM_003664
• Synonyms: ADTB3; ADTB3A; HPS; HPS2; PE
• Summary: This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]