Human PIAS1 activation kit by CRISPRa

CAT#: GA105666

PIAS1 CRISPRa kit - CRISPR gene activation of human protein inhibitor of activated STAT 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PIAS1
• Locus ID: 8554
• Kit Components:

  GA105666G1, PIAS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105666G2, PIAS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105666G3, PIAS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001320687, NM_016166
• Synonyms: DDXBP1; GBP; GU/RH-II; ZMIZ3
• Summary: This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]