Human DEGS1 activation kit by CRISPRa

CAT#: GA105672

DEGS1 CRISPRa kit - CRISPR gene activation of human delta 4-desaturase, sphingolipid 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DEGS1
• Locus ID: 8560
• Kit Components:

  GA105672G1, DEGS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105672G2, DEGS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105672G3, DEGS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001321541, NM_001321542, NM_003676, NM_144780
• Synonyms: DEGS; DEGS-1; Des-1; DES1; FADS7; MIG15; MLD
• Summary: This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010]