Human AKR7A2 activation kit by CRISPRa

CAT#: GA105684

AKR7A2 CRISPRa kit - CRISPR gene activation of human aldo-keto reductase family 7 member A2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AKR7A2
• Locus ID: 8574
• Kit Components:

  GA105684G1, AKR7A2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105684G2, AKR7A2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105684G3, AKR7A2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003689, NM_001320979
• Synonyms: AFAR; AFAR1; AFB1-AR1; AKR7
• Summary: The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]