Human KLF7 activation kit by CRISPRa

CAT#: GA105699

KLF7 CRISPRa kit - CRISPR gene activation of human Kruppel like factor 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLF7
• Locus ID: 8609
• Kit Components:

  GA105699G1, KLF7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105699G2, KLF7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105699G3, KLF7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001270942, NM_001270943, NM_001270944, NM_003709, NR_073108
• Synonyms: UKLF
• Summary: The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]