Human VAP1 (AOC3) activation kit by CRISPRa

CAT#: GA105723

AOC3 CRISPRa kit - CRISPR gene activation of human amine oxidase copper containing 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AOC3
• Locus ID: 8639
• Kit Components:

  GA105723G1, AOC3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105723G2, AOC3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105723G3, AOC3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001277731, NM_001277732, NM_003734, NR_102422
• Synonyms: HPAO; SSAO; VAP-1; VAP1
• Summary: This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]