Human Chordin (CHRD) activation kit by CRISPRa

CAT#: GA105729

CHRD CRISPRa kit - CRISPR gene activation of human chordin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHRD
• Locus ID: 8646
• Kit Components:

  GA105729G1, CHRD gRNA vector 1 in pCas-Guide-CRISPRa

  GA105729G2, CHRD gRNA vector 2 in pCas-Guide-CRISPRa

  GA105729G3, CHRD gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001304472, NM_001304473, NM_001304474, NM_003741, NM_177978, NM_177979, NR_130747
• Summary: This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015]