Human NCOA1 activation kit by CRISPRa

CAT#: GA105731

NCOA1 CRISPRa kit - CRISPR gene activation of human nuclear receptor coactivator 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NCOA1
• Locus ID: 8648
• Kit Components:

  GA105731G1, NCOA1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105731G2, NCOA1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105731G3, NCOA1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003743, NM_147223, NM_147233, NM_001362950, NM_001362952, NM_001362954, NM_001362955
• Synonyms: bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160; SRC1
• Summary: The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]