Human SOCS1 activation kit by CRISPRa

CAT#: GA105734

SOCS1 CRISPRa kit - CRISPR gene activation of human suppressor of cytokine signaling 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SOCS1
• Locus ID: 8651
• Kit Components:

  GA105734G1, SOCS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105734G2, SOCS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105734G3, SOCS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003745
• Synonyms: CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3
• Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]