Human PDE5A activation kit by CRISPRa

CAT#: GA105736

PDE5A CRISPRa kit - CRISPR gene activation of human phosphodiesterase 5A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDE5A
• Locus ID: 8654
• Kit Components:

  GA105736G1, PDE5A gRNA vector 1 in pCas-Guide-CRISPRa

  GA105736G2, PDE5A gRNA vector 2 in pCas-Guide-CRISPRa

  GA105736G3, PDE5A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001083, NM_033430, NM_033431, NM_033437
• Synonyms: CGB-PDE; CN5A; PDE5
• Summary: This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]