Human IRS2 activation kit by CRISPRa

CAT#: GA105740

IRS2 CRISPRa kit - CRISPR gene activation of human insulin receptor substrate 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IRS2
• Locus ID: 8660
• Kit Components:

  GA105740G1, IRS2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105740G2, IRS2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105740G3, IRS2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003749
• Synonyms: IRS-2
• Summary: This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]