Human EIF3D activation kit by CRISPRa

CAT#: GA105744

EIF3D CRISPRa kit - CRISPR gene activation of human eukaryotic translation initiation factor 3 subunit D

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EIF3D
• Locus ID: 8664
• Kit Components:

  GA105744G1, EIF3D gRNA vector 1 in pCas-Guide-CRISPRa

  GA105744G2, EIF3D gRNA vector 2 in pCas-Guide-CRISPRa

  GA105744G3, EIF3D gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003753, NR_156418
• Synonyms: eIF3-p66; eIF3-zeta; EIF3S7
• Summary: Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]