Human Beclin 1 (BECN1) activation kit by CRISPRa

CAT#: GA105757

BECN1 CRISPRa kit - CRISPR gene activation of human beclin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BECN1
• Locus ID: 8678
• Kit Components:

  GA105757G1, BECN1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105757G2, BECN1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105757G3, BECN1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001313998, NM_001313999, NM_001314000, NM_003766
• Synonyms: ATG6; beclin1; VPS30
• Summary: This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]