Human MRP3 (ABCC3) activation kit by CRISPRa

CAT#: GA105782

ABCC3 CRISPRa kit - CRISPR gene activation of human ATP binding cassette subfamily C member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ABCC3
• Locus ID: 8714
• Kit Components:

  GA105782G1, ABCC3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105782G2, ABCC3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105782G3, ABCC3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001144070, NM_003786, NM_020037, NM_020038
• Synonyms: ABC31; cMOAT2; EST90757; MLP2; MOAT-D; MRP3
• Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]