Human RAIDD (CRADD) activation kit by CRISPRa

CAT#: GA105802

CRADD CRISPRa kit - CRISPR gene activation of human CASP2 and RIPK1 domain containing adaptor with death domain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CRADD
• Locus ID: 8738
• Kit Components:

  GA105802G1, CRADD gRNA vector 1 in pCas-Guide-CRISPRa

  GA105802G2, CRADD gRNA vector 2 in pCas-Guide-CRISPRa

  GA105802G3, CRADD gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001320099, NM_001320100, NM_001320101, NM_001330126, NM_003805, NR_135147
• Synonyms: MRT34; RAIDD
• Summary: This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]