Human DLK (DLK1) activation kit by CRISPRa

CAT#: GA105835

DLK1 CRISPRa kit - CRISPR gene activation of human delta like non-canonical Notch ligand 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DLK1
• Locus ID: 8788
• Kit Components:

  GA105835G1, DLK1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105835G2, DLK1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105835G3, DLK1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001032997, NM_001317172, NM_003836
• Synonyms: delta-like 1 homolog; delta-like 1 homolog (Drosophila); delta-like homolog; DLK; FA1; FA1, ZOG, pG2, PREF1, Pref-1; pG2; Pref-1; PREF1; secredeltin; ZOG
• Summary: This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]