Human RANK (TNFRSF11A) activation kit by CRISPRa

CAT#: GA105838

TNFRSF11A CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 11a

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFRSF11A
• Locus ID: 8792
• Kit Components:

  GA105838G1, TNFRSF11A gRNA vector 1 in pCas-Guide-CRISPRa

  GA105838G2, TNFRSF11A gRNA vector 2 in pCas-Guide-CRISPRa

  GA105838G3, TNFRSF11A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001270949, NM_001270950, NM_001270951, NM_001278268, NM_003839
• Synonyms: CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TRANCER
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]