Human DcR1 (TNFRSF10C) activation kit by CRISPRa

CAT#: GA105840

TNFRSF10C CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 10c

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFRSF10C
• Locus ID: 8794
• Kit Components:

  GA105840G1, TNFRSF10C gRNA vector 1 in pCas-Guide-CRISPRa

  GA105840G2, TNFRSF10C gRNA vector 2 in pCas-Guide-CRISPRa

  GA105840G3, TNFRSF10C gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003841
• Synonyms: CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]