Human SUCLA2 activation kit by CRISPRa

CAT#: GA105849

SUCLA2 CRISPRa kit - CRISPR gene activation of human succinate-CoA ligase ADP-forming beta subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SUCLA2
• Locus ID: 8803
• Kit Components:

  GA105849G1, SUCLA2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105849G2, SUCLA2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105849G3, SUCLA2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003850
• Synonyms: A-BETA; MTDPS5; SCS-betaA
• Summary: Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]