Human TIF1 alpha (TRIM24) activation kit by CRISPRa

CAT#: GA105851

TRIM24 CRISPRa kit - CRISPR gene activation of human tripartite motif containing 24

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRIM24
• Locus ID: 8805
• Kit Components:

  GA105851G1, TRIM24 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105851G2, TRIM24 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105851G3, TRIM24 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003852, NM_015905
• Synonyms: hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1A; TIF1ALPHA
• Summary: The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]