Human IL18R1 activation kit by CRISPRa

CAT#: GA105854

IL18R1 CRISPRa kit - CRISPR gene activation of human interleukin 18 receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL18R1
• Locus ID: 8809
• Kit Components:

  GA105854G1, IL18R1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105854G2, IL18R1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105854G3, IL18R1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282399, NM_003855
• Synonyms: CD218a; CDw218a; IL-1Rrp; IL1RRP; IL18RA
• Summary: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]