Human HDAC3 activation kit by CRISPRa

CAT#: GA105883

HDAC3 CRISPRa kit - CRISPR gene activation of human histone deacetylase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HDAC3
• Locus ID: 8841
• Kit Components:

  GA105883G1, HDAC3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105883G2, HDAC3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105883G3, HDAC3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003883, NM_001355039, NM_001355040, NM_001355041, NR_149164, NR_149165, NR_149166, NR_149167, NR_149168, NR_149169
• Synonyms: HD3; RPD3; RPD3-2
• Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]