Human KAT2B activation kit by CRISPRa

CAT#: GA105889

KAT2B CRISPRa kit - CRISPR gene activation of human lysine acetyltransferase 2B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KAT2B
• Locus ID: 8850
• Kit Components:

  GA105889G1, KAT2B gRNA vector 1 in pCas-Guide-CRISPRa

  GA105889G2, KAT2B gRNA vector 2 in pCas-Guide-CRISPRa

  GA105889G3, KAT2B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003884
• Synonyms: CAF; P/CAF; PCAF
• Summary: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]