Human Protein Z (PROZ) activation kit by CRISPRa

CAT#: GA105896

PROZ CRISPRa kit - CRISPR gene activation of human protein Z, vitamin K dependent plasma glycoprotein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PROZ
• Locus ID: 8858
• Kit Components:

  GA105896G1, PROZ gRNA vector 1 in pCas-Guide-CRISPRa

  GA105896G2, PROZ gRNA vector 2 in pCas-Guide-CRISPRa

  GA105896G3, PROZ gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256134, NM_003891
• Synonyms: PZ
• Summary: This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]