Human Apelin (APLN) activation kit by CRISPRa

CAT#: GA105899

APLN CRISPRa kit - CRISPR gene activation of human apelin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: APLN
• Locus ID: 8862
• Kit Components:

  GA105899G1, APLN gRNA vector 1 in pCas-Guide-CRISPRa

  GA105899G2, APLN gRNA vector 2 in pCas-Guide-CRISPRa

  GA105899G3, APLN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_017413
• Synonyms: APEL; XNPEP2
• Summary: This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016]