Human Apc6 (CDC16) activation kit by CRISPRa

CAT#: GA105914

CDC16 CRISPRa kit - CRISPR gene activation of human cell division cycle 16

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDC16
• Locus ID: 8881
• Kit Components:

  GA105914G1, CDC16 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105914G2, CDC16 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105914G3, CDC16 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001078645, NM_001318517, NM_001318518, NM_001330101, NM_001330104, NM_001330105, NM_003903
• Synonyms: ANAPC6; APC6; CDC16Hs; CUT9
• Summary: The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]