Human ZNF259 (ZPR1) activation kit by CRISPRa

CAT#: GA105915

ZPR1 CRISPRa kit - CRISPR gene activation of human ZPR1 zinc finger

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ZPR1
• Locus ID: 8882
• Kit Components:

  GA105915G1, ZPR1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105915G2, ZPR1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105915G3, ZPR1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317086, NM_003904
• Synonyms: ZNF259
• Summary: The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]