Human EIF2B3 activation kit by CRISPRa

CAT#: GA105922

EIF2B3 CRISPRa kit - CRISPR gene activation of human eukaryotic translation initiation factor 2B subunit gamma

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EIF2B3
• Locus ID: 8891
• Kit Components:

  GA105922G1, EIF2B3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105922G2, EIF2B3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105922G3, EIF2B3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166588, NM_001261418, NM_020365
• Synonyms: EIF-2B; EIF2Bgamma
• Summary: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]