Human SGCE activation kit by CRISPRa

CAT#: GA105938

SGCE CRISPRa kit - CRISPR gene activation of human sarcoglycan epsilon

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SGCE
• Locus ID: 8910
• Kit Components:

  GA105938G1, SGCE gRNA vector 1 in pCas-Guide-CRISPRa

  GA105938G2, SGCE gRNA vector 2 in pCas-Guide-CRISPRa

  GA105938G3, SGCE gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001099400, NM_001099401, NM_001301139, NM_003919, NM_001346713, NM_001346715, NM_001346717, NM_001346719, NM_001346720, NM_001362809, NM_001362807, NM_001362808
• Synonyms: DYT11; ESG
• Summary: This gene encodes the epsilon member of the sarcoglycan family. Sarcoglycans are transmembrane proteins that are components of the dystrophin-glycoprotein complex, which link the actin cytoskeleton to the extracellular matrix. Unlike other family members which are predominantly expressed in striated muscle, the epsilon sarcoglycan is more broadly expressed. Mutations in this gene are associated with myoclonus-dystonia syndrome. This gene is imprinted, with preferential expression from the paternal allele. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene associated with this gene is located on chromosome 2. [provided by RefSeq, Oct 2016]