Human SCAP2 (SKAP2) activation kit by CRISPRa

CAT#: GA105955

SKAP2 CRISPRa kit - CRISPR gene activation of human src kinase associated phosphoprotein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SKAP2
• Locus ID: 8935
• Kit Components:

  GA105955G1, SKAP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105955G2, SKAP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105955G3, SKAP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001303468, NM_003930
• Synonyms: PRAP; RA70; SAPS; SCAP2; SKAP-HOM; SKAP55R
• Summary: The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]